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SEH-IN-21

CAT: 0931-T211654-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211654-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3084814-46-7
Target
Epoxide Hydrolase, Interleukin, NF-κB, TNF
Related Pathways
Metabolism, Apoptosis, Immunology/Inflammation, NF-κB
Bioactivity
SEH-IN-21 is an orally active inhibitor of sEH, exhibiting IC50 values of 0.1 nM for both hsEH and msEH. It significantly suppresses the NF-κB signaling pathway. sEH-IN-21 demonstrates potent anti-inflammatory activity by reducing IL-6 and TNF-α release and maintaining intestinal barrier integrity. It is applicable in research on inflammatory bowel disease (IBD) .
Smiles
N(C(N[C@H]1CC[C@H](NC2=C(NS(=O)(=O)C3=CC=C(C)C=C3)C(=O)C2=O)CC1)=O)C45CC6(C)CC(C)(C4)CC(C5)C6
Molecular Formula
C30H40N4O5S
Molecular Weight
568.73
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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