AChE/Aβ-IN-4

AChE/Aβ-IN-4

• UNSPSC Description: AChE/Aβ-IN-4 is a dual inhibitor of acetylcholinesterase (AChE) and β-amyloid (Aβ) aggregation, with the IC50 values of 1.72 ± 0.18 μM and 1.42 ± 0.3 μM, respectively. AChE/Aβ-IN-4 plays an impotant role in neurological disorders, such as Alzheimer’s disease[1].
• Target Antigen: Amyloid-β; Cholinesterase (ChE)
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/ache-aβ-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC1=CC=C(C)C=C1)CN2CCN(C3=CC(NC4=C3C=C(C)C=C4)=O)CC2
• Molecular Weight: 390.48
• References & Citations: [1]Shoaib Manzoor, et al. Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer’s Disease Therapy. ACS Chem Neurosci. 2023 Dec 27.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported