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AChE/Aβ-IN-4

CAT: 0804-HY-157441Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157441Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE/Aβ-IN-4 is a dual inhibitor of acetylcholinesterase (AChE) and β-amyloid (Aβ) aggregation, with the IC50 values of 1.72 ± 0.18 μM and 1.42 ± 0.3 μM, respectively. AChE/Aβ-IN-4 plays an impotant role in neurological disorders, such as Alzheimer’s disease[1].
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-aβ-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C)C=C1)CN2CCN(C3=CC(NC4=C3C=C(C)C=C4)=O)CC2
Molecular Formula
C23H26N4O2
Molecular Weight
390.48
References & Citations
[1]Shoaib Manzoor, et al. Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer’s Disease Therapy. ACS Chem Neurosci. 2023 Dec 27.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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