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Nrf2 degrader 30

CAT: 0931-T201395-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T201395-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3025286-29-4
Target
Nrf2, PROTACs
Related Pathways
PROTAC, Immunology/Inflammation
Purity
0.9881
Bioactivity
Nrf2 degrader 30 is a small molecule PROTAC that inhibits the degradation of Nrf2, thereby enhancing its activity. Nrf2 is a key transcription factor that regulates cellular antioxidant responses and various protective mechanisms. The activity of Nrf2 is primarily regulated by its interaction with Keap1, which serves as an E3 ubiquitin ligase complex adapter to promote Nrf2 ubiquitination and proteasomal degradation。
Smiles
O=C(C1=CN=CN1C)N2C3=CC=C(C=C3CC2)C=4N=C(SC4C)NC(=O)CC5=CC=C(F)C(OCCOCCNC6=CC=C7C(=O)N(CC7=C6)C8C(=O)NC(=O)CC8)=C5
Molecular Formula
C42H41FN8O7S
Molecular Weight
820.89
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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