Nrf2-IN-3

• Target:

  Nrf2|||ROS

• Related Pathways:

  Immunology/Inflammation

• Purity:

  0.9807

• Bioactivity:

  Nrf2-IN-3 is a mKEAP1-selective NRF2 inhibitor that selectively binds KEAP1 mutants and restores their NRF2 inhibitory function by repairing the disrupted KEAP1/NRF2 interaction, and selectively sensitizes cisplatin in xenografts of mouse mKEAP1 cancer cells.

• Smiles:

  O=C (NN=CC=1C=CC=CC1O) CCCSCCCC (=O) NN=CC=2C=CC=CC2O

• Molecular Formula:

  C22H26N4O4S

• Molecular Weight:

  442.53

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  6325-13-9