Antitumor agent-174

CAT: 0931-MF-0117724-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0117724-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
HSP|||c-Myc|||CDK|||Wnt/beta-catenin
Related Pathways
Metabolism|||Cytoskeletal Signaling|||Stem Cells|||Cell Cycle/Checkpoint
Bioactivity
Antitumor agent-174 (Compound 10) directly binds to the N-terminal site of Hsp90, promoting the degradation of ?-catenin and thereby inhibiting Wnt/?-catenin signaling. This compound effectively suppresses the proliferation of colorectal cancer (CRC) cells, induces S and G2/M phase arrest, and prevents cell colony formation. It downregulates proteins such as CDK1, Cyclin D1, c-Myc, Cyclin B1, and Cyclin A2, while upregulating P21. Antitumor agent-174 exhibits significant antitumor activity against CRC, offering excellent pharmacokinetics and low toxicity.
Molecular Formula
C20H18Cl2N2
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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