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HuR degrader 2

CAT: 0931-T210362-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210362-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3040301-46-7
Target
HuR, Molecular Glues
Related Pathways
Chromatin/Epigenetic, PROTAC
Bioactivity
HuRdegrader 2 (Compound 3) is a molecular glue that targets and degrades the RNA-binding protein Hu antigen R (HuR), achieving 30% degradation at 0.1 μM. It inhibits the proliferation of Colo-205 cancer cells with an IC50 of ≤200 nM. HuRdegrader 2 also shows high affinity for cereblon with an HTRF ratio < 0.02.
Smiles
O=C1NC(=O)C(C2=COC=3C=C(C=CC32)C=4C=CN=C5NC=CC54)CC1
Molecular Formula
C20H15N3O3
Molecular Weight
345.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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