Products for Research Use Only
RegisterLogin

PDL1 degrader-2

CAT: 0931-T201649-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T201649-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Ligands for Target Protein for PROTAC, Autophagy, PD-1/PD-L1, AUTACs
Related Pathways
Immunology/Inflammation, Cell Cycle/Checkpoint, Autophagy, Apoptosis, PROTAC
Bioactivity
PD-L1degrader-2 (Compound B3) is an orally effective AUTAC degrader that degrades PD-L1 via the autophagy-lysosome pathway with a DC50 of 0.5 μM. It inhibits the interaction between PD-1 and PD-L1, with an IC50 of 22.8 nM. PD-L1degrader-2 upregulates the expression of Atg9b, Lamp1, and Mitf, activating the autophagy-lysosome system. It exhibits antitumor activity in the CT26 mouse model.
Molecular Formula
C45H48N8O5
Molecular Weight
780.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T209911-01BRD4 degrader-2
T88651-01BRD9 Degrader-2
T86708-01IKZF1-degrader-2
T211571-01LCK degrader-2
T201799-01VAV1 degrader-2
T89344-01CDK2 degrader 2
T212332-01ALK degrader 2
T200322-01HSD17B13 degrader 2
T89279-01AR Degrader-2
T89038-01WIZ degrader 2

Alternative Products

CatalogName
HY-169363-01PDL1 degrader-2
HY-168530-01PDL1 degrader-1
HY-157569PD1-PDL1-IN 2
MBS578202PD1-PDL1 inhibitor 2
RG-1454MKN45-CLDN18.2-PDL1 Overexpressing Cell Line
RG-1295HEK293T-CLDN18.2-PDL1 Overexpressing Cell Line
A15906-100BMS-202 (PD1-PDL1 inhibitor 2) 100mg
A15906-25BMS-202 (PD1-PDL1 inhibitor 2) 25mg
A15906-5BMS-202 (PD1-PDL1 inhibitor 2) 5mg
A15906-2BMS-202 (PD1-PDL1 inhibitor 2) 2mg

Popular Products