ZG-2291

• Bioactivity:

  ZG-2291 is a selective inhibitor targeting FIH (hypoxia-inducible factor inhibitor) with oral activity. It selectively inhibits FIH by binding to it and inducing a conformational flip in a catalytically crucial tyrosine, without affecting other 2OG oxidases of the JmjC subfamily. ZG-2291 promotes thermogenesis and ameliorates obesity symptoms and metabolic dysfunctions in ob/ob mice. This compound holds promise for research in the field of obesity-related diseases.

• Smiles:

  O=C(O)CNC(=O)C=1N=CC(=CC1O)C=2ON=C(C2)C=3C=CC=C(Cl)C3

• Molecular Formula:

  C17H12ClN3O5

• Molecular Weight:

  373.75

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2962103-40-6