Antitumor agent-169

CAT: 0931-T210150-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T210150-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

PARP, PD-1/PD-L1

Related Pathways

DNA Damage/DNA Repair, Chromatin/Epigenetic, Immunology/Inflammation, Cell Cycle/Checkpoint, Apoptosis

Bioactivity

Antitumor agent-169 (Compound B3) is a dual inhibitor of PD-1/PD-L1 interaction and PARP7, with IC50 values of 0.426 μM and 2.50 nM, respectively. It exhibits affinity for human PD-L1 with a Ki of 20.2 nM and can restore T cell function by increasing IFN-γ secretion. Antitumor agent-169 inhibits cell viability in MDA-MB-231 and Jurkat T cells, demonstrates antitumor activity against melanoma in mouse models, and possesses favorable pharmacokinetic properties.

Molecular Formula

C55H69F3N10O10

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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