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PROTAC AR Degrader-9

CAT: 0013-GTR19250297-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19250297-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC AR Degrader-9 (c6) is a heterobifunctional degrader that induces androgen receptor (AR) degradation with a DC50 of 262.38 nM in HDPC cells. It upregulates TGF-β1 and β-catenin, demonstrating efficacy in promoting hair regeneration in mouse models, making it a tool for studying androgen signaling and alopecia.
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
C1CC (CN (C1) C2=CC=C (C=C2) C (=O) NC3CCC (=O) NC3=O) CN4CCC (CC4) C5=CC=C (C=C5) C (=O) NC6CCC (CC6) OC7=CC (=C (C=C7) C#N) Cl
Molecular Formula
C43H49ClN6O5
Molecular Weight
765.339
Storage Conditions
-20°C
Notes
For research use only.

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