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PROTAC BTK Degrader-1

CAT: 0931-T74636-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74636-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2801715-13-7
Target
Others, BTK, PROTACs
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, PROTAC, Others
Bioactivity
PROTAC BTK Degrader-1, a powerful, selective, and orally bioavailable degrader of PROTAC BTK, demonstrates effective reduction in BTK protein levels and tumor suppression. It exhibits IC50 values of 34.51 nM for BTK WT and 64.56 nM for BTK-481S, highlighting its potency and efficacy in targeting and diminishing BTK protein abundance [1].
Smiles
Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCN(CC1)C1CCN(CC#Cc2ccc3C(=O)N(Cc3c2)C2CCC(=O)NC2=O)CC1
Molecular Formula
C43H43N9O4
Molecular Weight
749.86
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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