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Antitumor agent-190

CAT: 0931-T206810-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206810-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Hexokinase, Reactive Oxygen Species, ROS, Microtubule Associated
Related Pathways
NF-κB, Cytoskeletal Signaling, Immunology/Inflammation, Metabolism
Bioactivity
Antitumor agent-190 (Compound 26) is a hexokinase 2 (Hexokinase2) inhibitor that exhibits significant antitumor activity by targeting both microtubules and hexokinase 2 (Hexokinase2), with an IC50 value of 0.764 μM against MD-MBA-231 cells. It effectively suppresses Hexokinase2 activity, resulting in the accumulation of reactive oxygen species (Reactive Oxygen Species) and disruption of mitochondrial membrane potential (MMP), thus promoting apoptosis and causing cell cycle arrest.
Smiles
C1COCCN1C2=CC3=C(C=C2)N(C=C3/C=C/C(=O)C4=CN=CC=C4)S(=O)(=O)C5=CC=C(C=C5)[N+](=O)[O-]
Molecular Formula
C26H22N4O6S
Molecular Weight
518.541
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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