Antitumor agent-201

CAT: 0931-MF-0114710-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0114710-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis|||Chloride channel|||Autophagy
Related Pathways
Autophagy|||Membrane transporter/Ion channel|||Apoptosis
Bioactivity
Antitumor agent-201 (Compound 10) is a Golgi apparatus-targeting chloride ion transport activator with an EC50 for promoting transmembrane chloride ion transport of 1.53 mol% and an IC50 against HepG2 cells of 7.13 ?M. By selectively acting on the Golgi apparatus, Antitumor agent-201 disrupts chloride ion homeostasis, decreases the expression of key proteins such as GM130 and GRASP55, and alters Golgi structure and function. This process induces Golgi apparatus autophagy, triggers apoptosis in cancer cells, and causes cell cycle arrest at the G2/M phase, thereby exhibiting anticancer activity. Antitumor agent-201 is applicable for research in the field of cancer-related diseases.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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