HCAIX-IN-23

CAT: 0931-MF-0110299-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0110299-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Carbonic Anhydrase|||Apoptosis|||Ferroptosis|||Reactive Oxygen Species|||Caspase|||Mitochondrial Metabolism
Related Pathways
Immunology/Inflammation|||NF-?B|||Metabolism|||Apoptosis|||Proteases/Proteasome
Bioactivity
HCAIX-IN-23 (Compound 27) is a human carbonic anhydrase (hCA) inhibitor with Ki values of 10.4 nM for hCA IX and 8.5 nM for hCA XII. It not only inhibits hCA activity but also releases NO, exerting dual anti-tumor effects. By reducing the expression of hCA IX and iron regulatory proteins, hCAIX-IN-23 regulates mitochondrial caspase activity and the ferroptosis pathway, thereby inducing apoptosis. This compound is utilized in research focused on renal cancer.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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