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HDAC-IN-79

CAT: 0931-T200527-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T200527-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Apoptosis, Autophagy, Xanthine Oxidase, HDAC
Related Pathways
Autophagy, Chromatin/Epigenetic, DNA Damage/DNA Repair, Metabolism, Apoptosis
Bioactivity
HDAC-IN-79 (compound 4) is an orally active dual inhibitor of xanthine oxidase and HDAC, exhibiting potent anti-hyperuricemia and antitumor activities in vivo (Xanthine oxidase: IC50=6.6 nM; HDAC1: IC50=134 nM; HDAC2: IC50=284 nM; HDAC3: IC50=173 nM; HDAC6: IC50=1.32 nM) . Among leukemia cells, it is most effective in inhibiting the growth of HL60 cells (IC50=0.706 μM) and induces both apoptosis and autophagy. HDAC-IN-79 also modulates the expression levels of biomarkers associated with intracellular HDAC inhibition.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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