HDAC-IN-79

• Target:

  Apoptosis|||Autophagy|||Xanthine Oxidase|||HDAC

• Related Pathways:

  Autophagy|||Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Metabolism|||Apoptosis

• Bioactivity:

  HDAC-IN-79 (compound 4) is an orally active dual inhibitor of xanthine oxidase and HDAC, exhibiting potent anti-hyperuricemia and antitumor activities in vivo (Xanthine oxidase: IC50=6.6 nM; HDAC1: IC50=134 nM; HDAC2: IC50=284 nM; HDAC3: IC50=173 nM; HDAC6: IC50=1.32 nM) . Among leukemia cells, it is most effective in inhibiting the growth of HL60 cells (IC50=0.706 ?M) and induces both apoptosis and autophagy. HDAC-IN-79 also modulates the expression levels of biomarkers associated with intracellular HDAC inhibition.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C