Products for Research Use Only
RegisterLogin

HDAC-IN-79

CAT: 0804-HY-162910Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-162910Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HDAC-IN-79 (compound 4) is an orally active dual xanthine oxidase-HDAC inhibitor (Xanthine oxidase: IC50=6.6 nM; HDAC1: IC50=134 nM; HDAC2: IC50=284 nM; HDAC3: IC50=173 nM; HDAC6: IC50=1.32 nM; ), with significant in vivo anti-hyperuricemia and anti-tumor activities. HDAC-IN-79 is the most potent cell growth inhibitor (IC50=0.706 μM) of leukemia HL60 cells, induces apoptosis and autophagy, and can regulate the expression levels of signature biomarkers associated with intracellular HDAC inhibition[1].
UNSPSC
12352211
Target
Apoptosis; Autophagy; HDAC; Xanthine Oxidase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hdac-in-79.html
Smiles
CC(C)COC1=CC=C(C2=NC(C)=C(C(NCCCCCCC(NO)=O)=O)S2)C=C1C#N
Molecular Formula
C23H30N4O4S
Molecular Weight
458.57
References & Citations
[1]Liao Z Y, et al. Rationally designed febuxostat-based hydroxamic acid and its pH-Responsive nanoformulation elicits anti-tumor activity[J]. European journal of medicinal chemistry, 279: 116866.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6

Related Products

CatalogName
HY-161688HDAC-IN-73
HY-161984HDAC-IN-76
HY-149370HDAC-IN-60
HY-142965HDAC-IN-28
HY-147892HDAC-IN-42
HY-162487HDAC-IN-72
HY-147966HDAC-IN-43
HY-18362HDAC-IN-5
HY-150597HDAC-IN-46
HY-168502HDAC-IN-81

Alternative Products

CatalogName
GTR19238848-01HDAC-IN-79
sc-19602MECA-79 (MECA-79)
T211349-01HDAC-IN-91
T210046-01HDAC-IN-75
T205411-01HDAC-IN-85
T203306-01HDAC-IN-82
T201210-01HDAC-IN-81
T200090-01HDAC-IN-76
T62514-01HDAC-IN-46
T62072-01HDAC-IN-47

Popular Products