AP-4-139B

• Description :

  AP-4-139B is a heat shock protein 70 inhibitor (IC50=180 nM) . HSP70 is a protein that is overexpressed in many types of cancer and is closely related to the survival and proliferation of tumor cells. AP-4-139B exhibits significant cytotoxicity to tumor cells, particularly in colorectal cancer cells. AP-4-139B can be used for cancer research[1][2].

• UNSPSC :

  12352005

• Target :

  HSP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ap-4-139b.html

• Purity :

  98.87

• Smiles :

  C1([P+](C2=CC=CC=C2)(C3=CC=CC=C3)CCCCCCC4=NN5C=C(N=C5S4)C6=CC=CC=C6)=CC=CC=C1.[Br-]

• Molecular Formula :

  C34H33BrN3PS

• Molecular Weight :

  626.59

• References & Citations :

  [1]Barnoud T, et al. A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors[J]. Cancer research, 2020, 80 (23) : 5270-5281.|[2]Ferretti G D S, et al. HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer[J]. Cell Death & Differentiation, 2024: 1-16.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HSP70

• CAS Number :

  [2716909-84-9]