STAT2 (Ab 690) Antibody

• Background:

  STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.

• NCBI Gene ID:

  6773

• Swiss Prot:

  P52630

• Accession Number:

  NP_005410.1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  STAT2 (Ab-690) antibody was raised against a peptide sequence around aa.688~692 (R-K-Y-L-K) derived from Human STAT2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer , Inflammasomes

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  113 kDa

• Specificity:

  This antibody detects endogenous level of total STAT2 protein.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

• Symbol:

  STAT2

• NCBI Official Name:

  Signal transducer and activator of transcription 2, 113kDa

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Fu, X. et al. (1992) Biochemistry 89, 7840-7843. Park, C. et al. (2000) Immunity 13, 795-804. Horvath, C. et al. (1996) Molecular and Cellular Biology 16, 6957-6964. Improta, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4776-4780.

• Other Product Names:

  P113, ISGF-3, STAT113, HYRC, HYRC1, P113

• Tested Applications:

  WB, IHC

• Protein ID:

  4885615

• Physical Properties:

  Liquid