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STAT2 (Ab 690) Antibody

CAT: 0223-79-429Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-429Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.
NCBI Gene ID
6773
Swiss Prot
P52630
Accession Number
NP_005410.1
Host
Rabbit
Reactivity
Human
Immunogen
STAT2 (Ab-690) antibody was raised against a peptide sequence around aa.688~692 (R-K-Y-L-K) derived from Human STAT2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer , Inflammasomes
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
113 kDa
Specificity
This antibody detects endogenous level of total STAT2 protein.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Symbol
STAT2
NCBI Official Name
Signal transducer and activator of transcription 2, 113kDa
NCBI Organism
Homo sapiens
Background Reference 01
Fu, X. et al. (1992) Biochemistry 89, 7840-7843. Park, C. et al. (2000) Immunity 13, 795-804. Horvath, C. et al. (1996) Molecular and Cellular Biology 16, 6957-6964. Improta, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4776-4780.
Other Product Names
P113, ISGF-3, STAT113, HYRC, HYRC1, P113
Tested Applications
WB, IHC
Protein ID
4885615
Physical Properties
Liquid

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