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STAT6 (Ab 641) Antibody

CAT: 0223-79-291Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-291Size:0.1 mg
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Background
STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. By screening an embryonic lung fibroblast cDNA library with a wildtype STAT6 probe, 2 variant cDNAs were identified, which were termed STAT6B and STAT6C, encoding an N-terminal 110-amino acid truncation and a 27-amino acid deletion in the SH2 domain, respectively. All the three variants are ubiquitously expressed with STAT6B expression greatest in spleen and STAT6C expression greatest in lung. STAT6B resembles an attenuated STAT6, but that STAT6C inhibits IL-4-mediated mitogenesis and cell surface antigen expression, and is not tyrosine phosphorylated
NCBI Gene ID
6778
Swiss Prot
P42226
Accession Number
NP_003144.3
Host
Rabbit
Reactivity
Human, Rat
Immunogen
STAT6 (Ab-641) antibody was raised against a peptide sequence around aa.639~643 (R-G-Y-V-P) derived from Human STAT6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
110 kDa
Specificity
This antibody detects endogenous level of total STAT6 protein.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Symbol
STAT6
NCBI Official Name
Signal transducer and activator of transcription 6, interleukin-4 induced
NCBI Organism
Homo sapiens
Background Reference 01
Nelms K, et al. (1999) Annu Rev Immunol. 17:701-738. Malabarba M G, et al. (1996) Biochem. J. 319:865-872. Hou J, et al. (1994) Science. 265:1701-1706. Quelle F W, et al. (1995) Mol Cell Biol. 15: 3336-3343. Takeda K, et al. (1996) Nature. 380: 627-630.
Other Product Names
STAT6B, STAT6C, D12S1644, IL-4-STAT, IL-4 Stat
Tested Applications
WB, IHC
Protein ID
23397678
Physical Properties
Liquid

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