STAT3 (Ab 727) Antibody

• Background:

  Transcription factor that binds to the interleukin-6 (IL-6) -responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

• NCBI Gene ID:

  6774

• Swiss Prot:

  P40763

• Accession Number:

  NP_003141.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  STAT3 (Ab-727) antibody was raised against a peptide sequence around aa. 725~729 (P-M-S-P-R) derived from Human STAT3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  88 kDa

• Specificity:

  This antibody detects endogenous level of total STAT3 protein.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

• Symbol:

  STAT3

• NCBI Official Name:

  Signal transducer and activator of transcription 3 (acute-phase response factor)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Heim M H, (1999) J Recept Signal Transduct Res. 19: 75-120. Takeda K, et al. (1997) Proc Natl Acad Sci USA. 94: 3801-3804. Catlett-Falcone R, et al. (1999) Immunity. 10: 105-115. Garcia R, et al. (1998) J Biomed Sci. 5: 79-85. Bromberg J F, et al. (1999) Cell. 98: 295-303.

• Other Product Names:

  APRF, HIES, BHLHE39, Acute-phase response factor

• Tested Applications:

  WB, IHC

• Protein ID:

  21618338

• Physical Properties:

  Liquid