STAT2 Antibody

• Background:

  The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

• NCBI Gene ID:

  6773

• Swiss Prot:

  P52630

• Accession Number:

  P52630

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This STAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-215 amino acids from the N-terminal region of human STAT2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Inflammasomes

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  98 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  STAT2

• NCBI Official Name:

  Signal transducer and activator of transcription 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Silva, L.K., et al. Eur. J. Hum. Genet. 18 (11) :1221-1227 (2010)

• Background Reference 02:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03:

  Han, S., et al. Hum. Immunol. 71 (7) :727-730 (2010)

• Background Reference 04:

  Lou, Y.J., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27 (3) :255-258 (2010)

• Other Product Names:

  Signal transducer and activator of transcription 2, p113, STAT2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  1711552

• Physical Properties:

  Liquid