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STAT2 Antibody

CAT: 0223-58-173Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-173Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.
NCBI Gene ID
6773
Swiss Prot
P52630
Accession Number
P52630
Host
Rabbit
Reactivity
Human
Immunogen
This STAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 820-851 amino acids from the C-terminal region of human STAT2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Inflammasomes
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
98 kDa
Fragment
Rabbit Ig
Symbol
STAT2
NCBI Official Name
Signal transducer and activator of transcription 2
NCBI Organism
Homo sapiens
Background Reference 01
Rodriguez, J.J., et al., J. Virol. 77 (21) :11842-11845 (2003) .
Background Reference 02
Gotoh, B., et al., J. Virol. 77 (6) :3360-3370 (2003) .
Background Reference 03
Saleh, A.Z., et al., Biochemistry 41 (37) :11261-11268 (2002) .
Background Reference 04
Rodriguez, J.J., et al., J. Virol. 76 (22) :11476-11483 (2002) .
Other Product Names
Signal transducer and activator of transcription 2, p113, STAT2
Tested Applications
WB, IHC-P
Protein ID
1711552
Physical Properties
Liquid

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