Products for Research Use Only
RegisterLogin

STAT1 (Ab 701) Antibody

CAT: 0223-79-285Size: 0.1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-79-285Size:0.1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs) . Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-γ -activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
NCBI Gene ID
6772
Swiss Prot
P42224
Accession Number
NP_009330.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
STAT1 (Ab-701) antibody was raised against a peptide sequence around aa. 699~703 (T-G-Y-I-K) derived from Human STAT1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer , Inflammasomes
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
91 kDa
Specificity
This antibody detects endogenous level of total STAT1 protein.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Symbol
STAT1
NCBI Official Name
Signal transducer and activator of transcription 1, 91kDa
NCBI Organism
Homo sapiens
Background Reference 01
Heim M H, (1999) J Recept Signal Transduct Res. 19: 75-120. Durbin J E, et al. (1996) Cell. 84: 443-450. Meraz M A, et al. (1996) Cell. 84: 431-442. Wakao H, et al. (1994) EMBO J. 13: 2182-2191. Demoulin J, B. et al. (1999) J Biol Chem. 274: 25855-258 Ihle J N, et al. (1994) Trends Biochem Sci. 19: 222-227.
Other Product Names
CANDF7, ISGF-3, STAT91, TRKB, Transcription factor ISGF-3 components p91/p84
Tested Applications
WB, IHC
Protein ID
6274552
Physical Properties
Liquid

Related Products

CatalogName
79-351STAT1 (Ab 727) Antibody
28-972STAT1 Antibody
64-232STAT1 Antibody
28-596STAT1 Antibody
14-249STAT1 Antibody
28-973STAT1 Antibody
27-842STAT1 Antibody
27-841STAT1 Antibody
1021-002mgSTAT1 alpha Antibody
1021-01mgSTAT1 alpha Antibody

Alternative Products

CatalogName
MBS8510284-01STAT1 (Ab-701) Antibody
MBS9438685-01STAT1 (Ab-701) Conjugated Antibody
35-1399-50Polyclonal Antibody to STAT1 (Ab-701)
bsm-70685MStat1 (Tyr-701), Phosphospecific Antibody
SM1351Anti-Stat1 (Tyr-701), Phosphospecific Antibody
E53P03322STAT1 (Ab-701) Rabbit Polyclonal Antibody
ANTY021044STAT1 (Ab-701)
Y021044Anti-STAT1 (Ab-701)
MBS470029-01Stat1 (Tyr-701), phospho-specific
AP21044Rabbit anti STAT1 (Ab-701)

Popular Products