STAT6 Antibody

STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.

6778

P42226

NP_003144

Human

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human STAT6.

Unconjugated

Primary Antibodies

Transcription, Cancer, Signal Transduction, Immunology

Antibody is purified by peptide affinity chromatography method.

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store STAT6 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

94 kDa

STAT6 antibody can be used for detection of STAT6 by ELISA at 1:62500. STAT6 antibody can be used for detection of STAT6 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

STAT6

Signal transducer and activator of transcription 6, interleukin-4 induced

Homo sapiens

Blanchard, C., (2005) Int. J. Biochem. Cell Biol. 37 (12), 2559-2573.

STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C

ELISA, WB

23397678