STAT6 Antibody

• Background:

  The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  6778

• Swiss Prot:

  P42226

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human STAT6 (NP_001171550.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction, Transcription

• Purification:

  Affinity purification

• Positive Control:

  MCF7

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 110kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  STAT6

• Positive Control 2:

  Jurkat

• Positive Control 3:

  HeLa

• Positive Control 4:

  Mouse spleen

• Positive Control 5:

  Mouse lung

• Positive Control 6:

  Mouse liver

• NCBI Official Name:

  Signal transducer and activator of transcription 6, interleukin-4 induced

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C

• Tested Applications:

  WB

• Physical Properties:

  Liquid