CD1E Antibody

• Background:

  CD1E encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members.

• NCBI Gene ID:

  913

• Swiss Prot:

  P15812

• Accession Number:

  P15812

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CD1E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-212 amino acids from the Central region of human CD1E.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CD1E

• NCBI Official Name:

  T-cell surface glycoprotein CD1e, membrane-associated

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Maitre, B., et al. Biochem. J. 419 (3) :661-668 (2009)

• Background Reference 02:

  Kuijf, M.L., et al. J. Neuroimmunol. 205 (1-2), 110-112 (2008)

• Background Reference 03:

  Maitre, B., et al. Traffic 9 (4) :431-445 (2008)

• Other Product Names:

  T-cell surface glycoprotein CD1e, membrane-associated, hCD1e, R2G1, CD1e, T-cell surface glycoprotein CD1e, soluble, sCD1e, CD1E

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  254763260

• Physical Properties:

  Liquid