CD1A Antibody

• Background:

  This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

• NCBI Gene ID:

  909

• Swiss Prot:

  P06126

• Accession Number:

  P06126

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CD1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 amino acids from the Central region of human CD1A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  37 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CD1A

• NCBI Official Name:

  T-cell surface glycoprotein CD1a

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zeissig, S., et al. J. Clin. Invest. 120 (8) :2889-2899 (2010)

• Background Reference 02:

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Background Reference 03:

  Valencia, J., et al. J. Leukoc. Biol. 87 (3) :405-414 (2010)

• Background Reference 04:

  Cernadas, M., et al. J. Immunol. 184 (3) :1235-1241 (2010)

• Other Product Names:

  T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, CD1a, CD1A

• Tested Applications:

  WB, IHC-P

• Protein ID:

  288558852

• Physical Properties:

  Liquid