EIF4A2 Antibody

• Background:

  Eukaryotic initiation factor 4A plays an important role in the binding of mRNA to the 43S preinitiation complex when protein synthesis begins. Two highly homologous forms of functional EIF4A genes, Eif4a1 and Eif4a2, have been isolated in mice; yeast cells also possess 2 EIF4A genes, TIF1 and TIF2. The murine Eif4a and yeast TIF genes appear to belong to a DEAD-box gene family, whose members exhibit extensive amino acid similarity and contain the asp-glu-ala-asp (DEAD) sequence. DEAD-box genes have been identified in species ranging from E-coli to humans. Their function appears to be related to transcriptional/translational regulation (referenced from OMIM) .

• NCBI Gene ID:

  1974

• Swiss Prot:

  Q14240

• Accession Number:

  Q14240

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This EIF4A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-360 amino acids from the C-terminal region of human EIF4A2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse, Rabbit, Chicken, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  46 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  EIF4A2

• NCBI Official Name:

  Eukaryotic initiation factor 4A-II

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Martins-de-Souza, D., et.al., Neural Transm 116 (3), 275-289 (2009)

• Background Reference 02:

  Lin, C.J., et.al., Cancer Res. 68 (13), 5326-5334 (2008)

• Other Product Names:

  Eukaryotic initiation factor 4A-II, eIF-4A-II, eIF4A-II, ATP-dependent RNA helicase eIF4A-2, EIF4A2, DDX2B, EIF4F

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  45645183

• Physical Properties:

  Liquid