EIF4G2 Antibody

• Background:

  Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

• NCBI Gene ID:

  1982

• Swiss Prot:

  P78344

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to a sequence within amino acids 750-850 of human EIF4G2 (NP_001409.3) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cell Cycle

• Purification:

  Affinity purification

• Positive Control:

  SW480

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 102kDa

• Fragment:

  IgG

• Symbol:

  EIF4G2

• Positive Control 2:

  A-549

• Positive Control 3:

  BT-474

• Positive Control 4:

  293T

• Positive Control 5:

  SH-SY5Y

• Positive Control 6:

  Mouse kidney

• NCBI Official Name:

  Eukaryotic translation initiation factor 4 gamma, 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  EIF4G2, AAG1, DAP5, FLJ41344, NAT1, p97, P97

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid