EIF4G2 Antibody

CAT: 0223-18-858Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-18-858Size:100 µL
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Background
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
NCBI Gene ID
1982
Swiss Prot
P78344
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 750-850 of human EIF4G2 (NP_001409.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle
Purification
Affinity purification
Positive Control
SW480
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 102kDa
Fragment
IgG
Symbol
EIF4G2
Positive Control 2
A-549
Positive Control 3
BT-474
Positive Control 4
293T
Positive Control 5
SH-SY5Y
Positive Control 6
Mouse kidney
NCBI Official Name
Eukaryotic translation initiation factor 4 gamma, 2
NCBI Organism
Homo sapiens
Other Product Names
EIF4G2, AAG1, DAP5, FLJ41344, NAT1, p97, P97
Tested Applications
WB, IHC
Physical Properties
Liquid

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