Tyrosinase Antibody

• Background:

  TYR catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The protein has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this protein result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation.

• NCBI Gene ID:

  7299

• Swiss Prot:

  P14679

• Accession Number:

  P14679

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This Tyrosinase antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 486-513 amino acids from the C-terminal region of human Tyrosinase.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TYR

• NCBI Official Name:

  Tyrosinase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ostankovitch, M. J. Immunol. 182 (8), 4830-4835 (2009)

• Background Reference 02:

  Chintamaneni, C.D. Proc. Natl. Acad. Sci. U.S.A. 88 (12), 5272-5276 (1991)

• Other Product Names:

  Tyrosinase, LB24-AB, Monophenol monooxygenase, SK29-AB, Tumor rejection antigen AB, TYR

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  401235

• Physical Properties:

  Liquid