Tyrosine Hydroxylase Antibody

• Background:

  Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999) . TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004) .

• NCBI Gene ID:

  25085

• Swiss Prot:

  P04177

• Accession Number:

  P04177

• Host:

  Rabbit

• Reactivity:

  Mammal

• Immunogen:

  SDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  Affinity Purified

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Tyrosine Hydroxylase antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

• Calculated Molecular Weight:

  60

• Specificity:

  Specific for the ~60k tyrosine hydroxylase protein.

• Symbol:

  Th

• NCBI Official Name:

  Tyrosine hydroxylase

• NCBI Organism:

  Rattus norvegicus

• Background Reference 01:

  Dunkley PR, Bobrovskaya L, Graham ME, Von Nagy-Felsobuki EI, Dickson PW (2004) Tyrosine hydroxylase phosphorylation: regulation and consequences. J Neurochem 91:1025-1043.

• Background Reference 02:

  Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567.

• Background Reference 03:

  Salvatore MF, Waymire JC, Haycock JW (2001) Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ. J Neurochem 79:349-360.

• Tested Applications:

  WB, IF, IHC

• Protein ID:

  136577

• Physical Properties:

  Liquid