Tyrosine Hydroxylase (phospho Ser40) Antibody

• Background:

  The protein encoded by Tyrosine Hydroxylase is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

• NCBI Gene ID:

  7054

• Swiss Prot:

  P07101

• Accession Number:

  NP_000351.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Tyrosine Hydroxylase (Phospho-Ser40) antibody was raised against a peptide sequence around phosphorylation site of serine 40 (R-Q-S (p) -L-I) derived from Human Tyrosine Hydroxylase (TH) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific, Neuroscience

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  55 - 60 kDa

• Specificity:

  This antibody detects endogenous level of TyrosineHydroxylase only when phosphorylated at serine 40.

• Applications Notes:

  Immunofluorescence: 1:100~1:200

• Symbol:

  TH

• NCBI Official Name:

  Tyrosine hydroxylase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vazin T, et al. Stem Cells. 2008 Jun;26 (6) : 1517-25Pistocchi A, et al. BMC Dev Biol. 2008 Mar 10;8:27 Fukakusa A, et al. J Pharmacol Sci. 2008 Feb;106 (2) : 321-4.

• Other Product Names:

  TYH, DYT14, DYT5b, MAPTL, MTBT1, TAU, TY3H, TYH, Tyrosine 3-hydroxylase, tyrosine hydroxylase

• Tested Applications:

  IF

• Protein ID:

  88900503

• Physical Properties:

  Liquid