CPSF6 Antibody

• Background:

  The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.

• NCBI Gene ID:

  11052

• Swiss Prot:

  Q16630

• Accession Number:

  Q16630

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CPSF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-51 amino acids from the N-terminal region of human CPSF6.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Zebrafish, Mouse, Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  59 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CPSF6

• NCBI Official Name:

  Cleavage and polyadenylation specificity factor subunit 6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lee, K., et al. Cell Host Microbe 7 (3) :221-233 (2010)

• Background Reference 02:

  Ruepp, M.D., et al. Mol. Biol. Cell 20 (24) :5211-5223 (2009)

• Background Reference 03:

  Xin, X., et al. Genome Res. 19 (7) :1262-1269 (2009)

• Background Reference 04:

  Maggi, L.B. Jr., et al. Mol. Cell. Biol. 28 (23) :7050-7065 (2008)

• Other Product Names:

  Cleavage and polyadenylation specificity factor subunit 6, Cleavage and polyadenylation specificity factor 68 kDa subunit, CFIm68, CPSF 68 kDa subunit, Pre-mRNA cleavage factor Im 68 kDa subunit, Protein HPBRII-4/7, CPSF6, CFIM68

• Tested Applications:

  WB

• Protein ID:

  88909266

• Physical Properties:

  Liquid