CPSF4 Antibody

CAT: 0223-64-029Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-64-029Size:400 µL
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Background
Inhibition of the nuclear export of poly (A) -containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.
NCBI Gene ID
10898
Swiss Prot
O95639
Accession Number
O95639
Host
Rabbit
Reactivity
Human
Immunogen
This CPSF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the Central region of human CPSF4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Rat, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
30 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CPSF4
NCBI Official Name
Cleavage and polyadenylation specificity factor subunit 4
NCBI Organism
Homo sapiens
Background Reference 01
Twu, K.Y., et al. J. Virol. 81 (15) :8112-8121 (2007)
Background Reference 02
Oh, J.H., et al. Mamm. Genome 16 (12) :942-954 (2005)
Background Reference 03
Kaufmann, I., et al. EMBO J. 23 (3) :616-626 (2004)
Background Reference 04
De Vries, H., et al. EMBO J. 19 (21) :5895-5904 (2000)
Other Product Names
Cleavage and polyadenylation specificity factor subunit 4, Cleavage and polyadenylation specificity factor 30 kDa subunit, CPSF 30 kDa subunit, NS1 effector domain-binding protein 1, Neb-1, No arches homolog, CPSF4, CPSF30, NAR, NEB1
Tested Applications
WB
Physical Properties
Liquid

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