CPSF3 Antibody

• Background:

  Most eukaryotic mRNA precursors (pre-mRNAs) undergo extensive maturational processing, including cleavage and polyadenylation at the 3-prime end. CPSF3 encodes the 73-kD subunit of the cleavage and polyadenylation specificity factor (CPSF) and is the pre-mRNA 3-prime-end-processing endonuclease (Mandel et al., 2006 [PubMed 17128255]) .

• NCBI Gene ID:

  51692

• Swiss Prot:

  Q9UKF6

• Accession Number:

  Q9UKF6

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CPSF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-221 amino acids from the Central region of human CPSF3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  77 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CPSF3

• NCBI Official Name:

  Cleavage and polyadenylation specificity factor subunit 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rozenblatt-Rosen, O., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (3) :755-760 (2009)

• Background Reference 02:

  Zhu, Z.H., et al. Oncogene 28 (1) :41-51 (2009)

• Background Reference 03:

  Yang, X.C., et al. Mol. Cell. Biol. 29 (1) :31-42 (2009)

• Background Reference 04:

  Kolev, N.G., et al. EMBO Rep. 9 (10) :1013-1018 (2008)

• Other Product Names:

  Cleavage and polyadenylation specificity factor subunit 3, 3127-, Cleavage and polyadenylation specificity factor 73 kDa subunit, CPSF 73 kDa subunit, mRNA 3'-end-processing endonuclease CPSF-73, CPSF3, CPSF73

• Tested Applications:

  WB

• Protein ID:

  18203503

• Physical Properties:

  Liquid