CPSF3 Antibody

• Background :

  Most eukaryotic mRNA precursors (pre-mRNAs) undergo extensive maturational processing, including cleavage and polyadenylation at the 3-prime end. CPSF3 encodes the 73-kD subunit of the cleavage and polyadenylation specificity factor (CPSF) and is the pre-mRNA 3-prime-end-processing endonuclease (Mandel et al., 2006 [PubMed 17128255]) .

• NCBI Gene ID :

  51692

• Swiss Prot :

  Q9UKF6

• Accession Number :

  Q9UKF6

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This CPSF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-221 amino acids from the Central region of human CPSF3.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  77 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  CPSF3

• NCBI Official Name :

  Cleavage and polyadenylation specificity factor subunit 3

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Rozenblatt-Rosen, O., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (3) :755-760 (2009)

• Background Reference 02 :

  Zhu, Z.H., et al. Oncogene 28 (1) :41-51 (2009)

• Background Reference 03 :

  Yang, X.C., et al. Mol. Cell. Biol. 29 (1) :31-42 (2009)

• Background Reference 04 :

  Kolev, N.G., et al. EMBO Rep. 9 (10) :1013-1018 (2008)

• Other Product Names :

  Cleavage and polyadenylation specificity factor subunit 3, 3127-, Cleavage and polyadenylation specificity factor 73 kDa subunit, CPSF 73 kDa subunit, mRNA 3'-end-processing endonuclease CPSF-73, CPSF3, CPSF73

• Tested Applications :

  WB

• Protein ID :

  18203503

• Physical Properties :

  Liquid