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JAK2 Antibody

CAT: 0223-8085-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8085-01Size:0.02 mg
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Background
JAK2 is a member of the JAK family of kinases that also include JAK1, JAK3, and TYK2 (1,2) . JAK kinases are activated following tyrosine phosphorylation of cytokine receptors after ligand binding. JAK2 activation promotes the recruitment and phosphorylation of STAT3 and STAT5. These transcription factors then translocate to the nucleus where they bind specific DNA promoter sequences resulting in the transcription of genes that regulate cell proliferation, differentiation, and apoptosis (3) . Mice with a disrupted JAK2 gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis (4) .
NCBI Gene ID
3717
Swiss Prot
O60674
Accession Number
NP_004963
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell, Apoptosis
Purification
JAK2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1212 - 3T3 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (100%), Chicken: (82%)
Buffer
JAK2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
JAK2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
JAK2 antibody is human, mouse and rat reactive. JAK2 antibody is predicted to not cross-react with other members of the JAK family of proteins.
Symbol
JAK2
NCBI Official Name
Janus kinase 2
NCBI Organism
Homo sapiens
Background Reference 01
Wilks AF, Harpur AG, Kurban RR, et al. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell Biol. 1991; 11:2057-66.
Background Reference 02
Quintas-Cardama A and Verstovsek S. Molecular pathways: JAK/STAT pathway: mutations, inhibitors, and resistance. Clin. Can. Res. 2013; 19:1933-40.
Background Reference 03
Levine RL, Pardanani A, Tefferi A, et al. Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders. Nat. Rev. Cancer 2007; 7:673-83.
Background Reference 04
Neubauer H, Cumano A, Muller M, et al. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 1998; 93:397-409.
Other Product Names
Janus kinase 2, JTK10, THCYT3
Tested Applications
ELISA, WB, IHC-P
Protein ID
4826776
Physical Properties
Liquid

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