JAK1 (phospho Tyr1022) Antibody

• Background:

  Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL) -2 receptor.

• NCBI Gene ID:

  3716

• Swiss Prot:

  P23458

• Accession Number:

  NP_002218.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  JAK1 (Phospho-Tyr1022) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1022 (K-E-Y (p) -Y-T) derived from Human JAK1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific, Apoptosis, Cancer

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  130 kDa

• Specificity:

  This antibody detects endogenous level of JAK1 only when phosphorylated at tyrosine 1022.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

• Symbol:

  JAK1

• NCBI Official Name:

  Janus kinase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zheng H, et al. (2005) Mol Cell Proteomics. 4 (6) : 721-730. Wang R, et al. (2003) Arch Biochem Biophys. 410 (1) : 7-15.

• Other Product Names:

  JTK3, JAK1A, JAK1B, AMPK1, Janus kinase 1

• Tested Applications:

  WB, IHC

• Protein ID:

  102469034

• Physical Properties:

  Liquid