TP-2

TP-2

• UNSPSC Description: TP-2, a caltrop-like multicationic small molecule, is an antidote that can completely neutralize both unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs). TP-2 is not only superior to protamine, has higher neutralization activity, but is also biocompatible[1].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/tp-2.html
• Solubility: 10 mM in DMSO
• Smiles: NCCOC1=C(C=CC(C2=CC=[N+](C=C2)CC3=CC=C(C(C4=CC=C(C=C4)C[N+]5=CC=C(C=C5)C6=CC(OCCN)=C(C=C6)OCCN)(C7=CC=C(C=C7)C[N+]8=CC=C(C=C8)C9=CC(OCCN)=C(C=C9)OCCN)C%10=CC=C(C=C%10)C[N+]%11=CC=C(C=C%11)C%12=CC(OCCN)=C(C=C%12)OCCN)C=C3)=C1)OCCN.[Cl-].[Cl-].[Cl-].[Cl-]
• Molecular Weight: 1607.63
• References & Citations: [1]Zong Y, et al. Caltrop-like Small-Molecule Antidotes That Neutralize Unfractionated Heparin and Low-Molecular-Weight Heparin In Vivo. J Med Chem. 2024 Feb 26.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported