U-104

• Description :

  U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model[1][2].

• Product Name Alternative :

  SLC-0111

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Carbonic Anhydrase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/U-104.html

• Purity :

  99.95

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=S(C1=CC=C(NC(NC2=CC=C(F)C=C2)=O)C=C1)(N)=O

• Molecular Formula :

  C13H12FN3O3S

• Molecular Weight :

  309.32

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Lou Y, et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 2011 May 1;71 (9) :3364-76.|[2]Lock FE, et al. Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. Oncogene. 2013 Oct 31;32 (44) :5210-9.|[3]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1322-1330.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  CA IX; CA XII

• CAS Number :

  [178606-66-1]