PROTAC TG2 degrader-2

PROTAC TG2 degrader-2

• UNSPSC Description: PROTAC TG2 degrader-2 (compound 7) is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. PROTAC TG2 degrader-2 inhibits the cell migration and decreases the level of TG2 in ovarian cancer cells. PROTAC TG2 degrader-2 can be used for ovarian cancer study[1].
• Target Antigen: Glutaminase; PROTACs
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-tg2-degrader-2.html
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: O=C(CCOCCN(C1=CC(C)=NC(NC2=CC=C(NC(CC3=CC=CC=C3)=O)C=C2)=N1)C)N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O
• Molecular Weight: 876.08
• References & Citations: [1]Valdivia A, el at. Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2). J Med Chem. 2023;66(14):9445-9465. doi:10.1021/acs.jmedchem.2c01859Valdivia A, Vagadia PP, Guo G, O'Brien E, Matei D, Schiltz GE. Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2). J Med Chem. 2023;66(14):9445-9465. doi:10.1021/acs.jmedchem.2c01859
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported