PROTAC TG2 degrader-1

PROTAC TG2 degrader-1

• CAS Number: 3033465-55-0
• UNSPSC Description: PROTAC TG2 degrader-1 (compound 11) is a von Hippel-Lindau (VHL)-based PROTAC targeting tissue transglutaminase (TG2) with a KD of 68.9 μM. PROTAC TG2 degrader-1 reduces TG2 in ovarian cancer cells in a proteasome-dependent manner[1].
• Target Antigen: Glutaminase; PROTACs
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-tg2-degrader-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCOCCOCCOCCOCCOCCN(C2=NC(NC3=CC=C(NC(CC4=CC=CC=C4)=O)C=C3)=NC(C)=C2)C)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
• Molecular Weight: 1052.29
• References & Citations: [1]Andres Valdivia, et al. Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2). J Med Chem. 2023 Jul 27;66(14):9445-9465.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported