SOS1-IN-17
CAT:
804-HY-168716
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
SOS1-IN-17
- UNSPSC Description: SOS1-IN-17 (Compound 8d) is an orally active inhibitor for SOS1-KRASG12C interaction with an IC50 of 5.1 nM. SOS1-IN-17 inhibits ERK phosphorylation in DLD-1 cell with an IC50 of 18 nM. SOS1-IN-17 exhibits anti-proliferative activity in KRASG12C mutated Mia-Paca-2 cell with an IC50 of 0.11 μM. SOS1-IN-17 exhibits antitumor efficacy against pancreatic cancer in mouse model[1].
- Target Antigen: Ras
- Type: Reference compound
- Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/sos1-in-17.html
- Smiles: FC1=C(C(F)F)C=CC=C1[C@H](NC2=NC(C)=NC3=C2C=C4C(OCCN4C(C5CCN(C(C)C)CC5)=O)=C3)C
- Molecular Weight: 541.61
- References & Citations: [1]Qing L, et al., Novel potent SOS1 inhibitors containing a tricyclic quinazoline scaffold: A joint view of experiments and simulations. Eur J Med Chem. 2025 Jan 15;282:117065.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported