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SOS1-IN-17

CAT: 0931-T203656-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T203656-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Ras, Raf
Related Pathways
MAPK, GPCR/G Protein
Bioactivity
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.
Molecular Formula
C29H34F3N5O2
Molecular Weight
541.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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