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U-46619

CAT: 0804-HY-108566-01Size: 1 mg (28.5 mM x 100 μL in Methyl Acetate)Dry Ice: NoHazardous: No
CAT#: HY-108566-01Size: 1 mg (28.5 mM x 100 μL in Methyl Acetate)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation[1][4][5].
CAS Number
[56985-40-1]
Product Name Alternative
9,11-Methanoepoxy PGH2
UNSPSC
12352005
Hazard Statement
H225, H319, H336
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/u-46619.html
Concentration
28.5 mM * 100 μL in Methyl acetate
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
O=C(O)CCC/C=C\C[C@H]1[C@@]2([H])CO[C@@](C2)([H])[C@@H]1/C=C/[C@@H](O)CCCCC
Molecular Formula
C21H34O4
Molecular Weight
350.49
Precautions
H225, H319, H336
References & Citations
[1]Ohkubo S, et al. Thromboxane A2-mediated shape change: independent of Gq-phospholipase C--Ca2+ pathway in rabbit platelets. Br J Pharmacol. 1996 Mar;117 (6) :1095-104.|[2]Su L, et al. The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways. Stem Cell Res Ther. 2018 Nov 15;9 (1) :313.|[3]Schirner M, et al. U 46619 induces different blood pressure effects in male and female spontaneously hypertensive rats (SHR) . Prostaglandins Leukot Essent Fatty Acids. 1993 Jun;48 (6) :469-73.|[4]Chen S, et al. Roles of the RhoA-ROCK Signaling Pathway in the Endothelial H2S Production and Vasodilation in Rat Cerebral Arteries. ACS Omega. 2022 May 20;7 (22) :18498-18508. |[5]Nie D, et al. Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho. Cancer Res. 2008 Jan 1;68 (1) :115-21.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TXA2/TP

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