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DPP-4-IN-11

CAT: 0804-HY-159491Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159491Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DPP-4-IN-11 (compound 10) is an orally active DPP-4 inhibitor (IC50=2.75 μM) with anti-type 2 diabetes activity. DPP-4-IN-11 exerts its glucose-lowering effect by inhibiting the activities of α-glucosidase (IC50=3.02 μM) and α-amylase (IC50=3.3 μM) [1].
UNSPSC
12352005
Target
Amylases; Dipeptidyl Peptidase; Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dpp-4-in-11.html
Smiles
OC1=CC=C(S(=O)(N2CCCC2)=O)C=C1/C=N/NC3=NC=C(C4=CC=CC=C4)S3
Molecular Formula
C20H20N4O3S2
Molecular Weight
428.53
References & Citations
[1]Thabet, et al. "Unveiling anti-diabetic potential of new thiazole-sulfonamide derivatives: Design, synthesis, in vitro bio-evaluation targeting DPP-4, α-glucosidase, and α-amylase with in-silico ADMET and docking simulation." Bioorganic Chemistry 151 (2024) : 107671.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DPP-4

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