DPP-4-IN-11

• UNSPSC Description:

  DPP-4-IN-11 (compound 10) is an orally active DPP-4 inhibitor (IC50=2.75 μM) with anti-type 2 diabetes activity. DPP-4-IN-11 exerts its glucose-lowering effect by inhibiting the activities of α-glucosidase (IC50=3.02 μM) and α-amylase (IC50=3.3 μM)[1].

• Target Antigen:

  Amylases; Dipeptidyl Peptidase; Glycosidase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/dpp-4-in-11.html

• Smiles:

  OC1=CC=C(S(=O)(N2CCCC2)=O)C=C1/C=N/NC3=NC=C(C4=CC=CC=C4)S3

• Molecular Weight:

  428.53

• References & Citations:

  [1]Thabet, et al. "Unveiling anti-diabetic potential of new thiazole-sulfonamide derivatives: Design, synthesis, in vitro bio-evaluation targeting DPP-4, α-glucosidase, and α-amylase with in-silico ADMET and docking simulation." Bioorganic Chemistry 151 (2024): 107671.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported