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Antimalarial agent 41

CAT: 0804-HY-163765Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163765Size:1 Each
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Description
Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC50 of 40 nM (NF54 strain) and 76 nM (K1 strain) . Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC50 of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC50 of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
PI4K; Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; PI3K/Akt/mTOR
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antimalarial-agent-41.html
Smiles
FC(C1=CC=C(C2=CC=C3N=CC=C(NC4CCNCC4)C3=N2)C=N1)(F)F
Molecular Formula
C19H18F3N5
Molecular Weight
373.37
References & Citations
[1]Dziwornu GA, et al., 2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy. J Med Chem. 2024 Jun 25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI4K

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