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WZH-17-002

CAT: 0013-GTR19263780-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263780-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WZH-17-002 is an ALKPROTAC degrader based on WZH-15-125, with a DC50 of 25 nM. This compound enhances the efficacy against ALK mutations that confer resistance to Lorlatinib. Moreover, WZH-17-002 significantly reduces resistance in ALK fusion non-small cell lung cancer (NSCLC) and inhibits tumor growth in EML4-ALK G1202R/L1196M xenograft mouse models.
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

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