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WZH-17-002

CAT: 0931-T211075-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211075-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
PROTACs, Akt, ERK, ALK
Related Pathways
Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Angiogenesis, MAPK, Tyrosine Kinase/Adaptors, PROTAC
Bioactivity
WZH-17-002 is an ALKPROTAC degrader based on WZH-15-125, with a DC50 of 25 nM. This compound enhances the efficacy against ALK mutations that confer resistance to Lorlatinib. Moreover, WZH-17-002 significantly reduces resistance in ALK fusion non-small cell lung cancer (NSCLC) and inhibits tumor growth in EML4-ALK G1202R/L1196M xenograft mouse models.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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