I3IN-002

CAT: 0804-HY-174228-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-174228-01Size:5 mg
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Description
I3IN-002 is a small-molecule RNA-binding protein IGF2BP3 inhibitor with an IC50 value of approximately 2 μM in SEM cells. I3IN-002 interferes with interaction with m6 A-modified mRNAs, disrupting the stabilization of target genes (such as CDK6, MYC, and BCL2) to inhibit leukemic cell growth, induce cell cycle arrest, and promote apoptosis. I3IN-002 is promising for research of B-cell acute lymphoblastic leukemia[1][2].
CAS Number
[552829-57-9]
UNSPSC
12352005
Target
Apoptosis; Insulin Receptor
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.35
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=C(C(F)(F)F)C=CC=C1)CSC(N=N2)=NC3=C2C4=CC(CC)=CC=C4N3
Molecular Formula
C20H16F3N5OS
Molecular Weight
431.43
References & Citations
[1]Jaiswal A K, et al. A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity[J]. bioRxiv, 2025: 2025.04. 14.648780.|[2]Sharma G, et al. Metabolic regulation of RNA methylation by the m6A-reader IGF2BP3. bioRxiv [Preprint]. 2024 Nov 3:2024.10.31.621399.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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