MG-002

CAT: 0013-GTR19274855-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19274855-01Size:10 mg

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Description

MG-002 is an orally active eIF4A inhibitor. It suppresses mRNA translation by non-productively clamping eukaryotic translation initiation factor 4A (eIF4A) onto RNA, thereby hindering ribosome recruitment and scanning. MG-002 selectively inhibits the growth and metastasis of triple-negative breast cancer (TNBC) tumors and induces apoptosis. It also significantly reduces the expression of c-MYC and cyclin D1 proteins. MG-002 is useful for TNBC research.

CAS Number

3076503-34-6

Smiles

O[C@]12[C@] ([C@@H] ([C@@H] (C (NOC) =O) [C@H]1O) C3=CC=CC=C3) (OC=4C2=C (OC) N=C (OC) C4) C5=CC=C (C#N) C=C5

Molecular Formula

C27H25N3O7

Molecular Weight

503.51

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

(2S,3R,4R,5S,6R)-6-(4-cyanophenyl)-2,3-dihydroxy-N,10,12-trimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.02,6]dodeca-1(12),8,10-triene-4-carboxamide

CAS Number	3076503-34-6
PubChem CID	176713582
IUPAC Name	(2S,3R,4R,5S,6R)-6-(4-cyanophenyl)-2,3-dihydroxy-N,10,12-trimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.02,6]dodeca-1(12),8,10-triene-4-carboxamide
Molecular Formula	C27H25N3O7
Molecular Weight	503.5
XLogP	2
Topological Polar Surface Area	143
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	6
Heavy Atom Count	37
Formal Charge	0
Complexity	882

SMILES

COC1=NC(=C2C(=C1)O[C@@]3([C@]2([C@@H]([C@@H]([C@H]3C4=CC=CC=C4)C(=O)NOC)O)O)C5=CC=C(C=C5)C#N)OC

InChI

InChI=1S/C27H25N3O7/c1-34-19-13-18-22(25(29-19)35-2)26(33)23(31)20(24(32)30-36-3)21(16-7-5-4-6-8-16)27(26,37-18)17-11-9-15(14-28)10-12-17/h4-13,20-21,23,31,33H,1-3H3,(H,30,32)/t20-,21-,23-,26+,27+/m1/s1

InChIKey

WTENXFJWMGLPQX-WFINZZCUSA-N

Chemical Structure

2D Structure

CAS: 3076503-34-6

CID: 176713582

Formula: C27H25N3O7

MW: 503.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	503.5
XLogP3	2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	6
Exact Mass	503.16925015
Monoisotopic Mass	503.16925015
Topological Polar Surface Area	143 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	882
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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MG-002

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